av NM Fischer · 2018 · Citerat av 28 — for breaking RNA atom-ion interactions) is found to tion shell to the RNA, diffuse Mg2+ ions that bind via mul- LINCS (71,72) algorithm.

We previously identified that the CpG island-associated promoter of the novel lincRNA ZNF300P1 (also known as LOC134466) is frequently hypermethylated and silenced in ovarian cancer tissues. However, the function of ZNF300P1 was unknown. In this report we demonstrate that ZNF300P1 is involved in the regulation of key cell cycle and cell motility networks in human ovarian surface epithelial

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Linc rna

(a) The expression of 19 candidate lincRNAs in ESCC and matched non-tumor esophagus specimens from 358 patients in lincRNA Identiﬁcation lincRNAs and lincRNA candidates have been cataloged in human, mouse, zebraﬁsh, frog, ﬂy, nematode, Arabidopsis, maize, and Plasmodium (Table 1). Interrogation of lincRNA func-tion or mechanisms depends on high-quality transcript models of lincRNA genes, including accurate genomic positions of the Through an integrative analysis of the lincRNA expression and tumor immune response in 9,626 tumor samples across 32 cancer types, we developed a lincRNA-based immune response (LIMER) score that can predict the immune cells infiltration and patient prognosis in multiple cancer types. Our analysis also identified tumor-specific lincRNAs, including EPIC1 , that potentially regulate tumor immune Hypoxia has long been linked to the Warburg effect, yet the underlying mechanism remains largely unclear. It is also not known if lncRNAs are involved in the contribution of hypoxia to the Warburg effect. Here we show that lincRNA-p21 is a hypoxia-responsive lncRNA and is essential for hypoxia-enhanced glycolysis. Hypoxia/HIF-1α-induced lincRNA-p21 is able to bind HIF-1α and VHL and thus LncRNAs make up a long non-coding portion of the transcriptome, often expressed at low levels. Yet, with their important roles in gene regulation, cell proli LincRNA‐Cox2 has been shown to mediate both the activation and repression of distinct classes of immune genes (23, 25, 26).

2、Intergenic lncRNA，基因间区的lncRNA，也称作lincRNA：主要产生于两个编码基因的中间区域； 3、Antisense lncRNA，反义lncRNA：主要产生于编码基因的反义链；具体如下图所示：按基因组上lncRNA的产生位置来分类（Scheuermannet al. The EMBO Journal,2013）

Line. mina owinir, licamlica oc andelica, ath jac rna wärdhelica. av A Seim · 2010 · Citerat av 1 — och RNA. Det finns olika Larson L. E., A. E. Aiellob, C. Gomez-Duartec, S. X. Linc, L. Leed, P. Della-Lattae, & C. Lindhardtf (2003). Roll av lång icke-kodande RNA-RNCR3 vid aterosklerosrelaterad vaskulär dysfunktion.

These lincRNA‐based prognostic biomarkers may destroy important cancer‐related biological processes contributing to LUAD prognosis. In summary, we demonstrate the prognostic potential of four differentially expressed lincRNAs with copy number alterations (RBPMS‐AS1, TDRKH‐AS1, LINC00578 and RP11‐470 M17.2) that are positively associated with longer overall survival of LUAD patients.

RNAcentral is the Jan 15, 2021 Linc-OIP5 lncRNA is upregulated in glioma tissue and positively correlates with glioma grade.

However, our understanding of lincRNA abundance and function remains very limited especially for agriculturally important plants. Long noncoding RNAs (lncRNAs) represent a class of transcribed RNA molecules that are longer than 200 nucleotides and yet do not encode proteins. Large intergenic noncoding RNAs (lincRNAs) are still poorly functionally characterized. We analyzed the genetic and epigenetic regulation of human lincRNA expression in the GenCord collection by using three cell types from 195 unrelated European individuals. lincRNA transcripts, while minimising disruption to the lincRNA gene (i.e., to test the function of the RNA product).
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LINC Model 3. rna för personal ocl"r chefer samt ati se över möjligheten att införa digital ;iiri:]i inorn iandstinEr*t ocl': *n cleira;;ande kornn-:linc:':'-!. y'i,\,'(:'rr. Katnreraren A. 1~/~ Linc/steflt,.

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2012-08-24 · We hypothesized that HuR might stabilize lincRNA-p21, as HuR stabilizes many mRNAs (Hinman and Lou, 2008).Forty-eight hours after silencing HuR using small interfering RNA (siRNA) in HeLa cells, we measured the steady-state lincRNA-p21 levels, as well as the lincRNA-p21 half-life after inhibiting transcription by incubating cells with actinomycin D and measuring the rate of lincRNA-p21

We analyzed the genetic and epigenetic regulation of human lincRNA expression in the GenCord collection by using three cell types from 195 unrelated European individuals. lincRNA transcripts, while minimising disruption to the lincRNA gene (i.e., to test the function of the RNA product). Overall, our in-depth analyses of 140 cell lines highlight two key aspects.

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lincRNA loci functioning in trans from those modulating local gene expression.Somegenesexpresssta bleand/orabundantlincRNAsin single cells, but many prematurely terminate transcription and produce lincRNAs rapidly degraded by the nuclear exosome. This suggests that besides RNA-dependent functions, lincRNA loci act as

lincRNA avser det långa intergena icke-kodande RNA medan lncRNA avser det långa icke-kodande RNA. lincRNA representerar den längsta gruppen av RNA som inte kodar. Å andra sidan representerar lncRNA en annan grupp av långt RNA som har cirka 200 nukleotider och som är kortare än lincRNA. LincRNA即Long intergenic non-coding RNA。. 人类细胞中仅有少数转录生成的RNAs可作为蛋白质合成的模板。.